Activities within ProMed Pharma are focused on manufacturing processes based on molding silicones or thermoplastics. While work has historically focused on molding silicone drug delivery devices using injection and compression molding techniques, new applications involving degradable and -nondegradable plastics are emerging.
Several factors must be considered in optimizing the material formulation and developing a robust molding process. The material system (e.g. liquid silicone vs. high consistency rubber), mixing or compounding technique, API particulate size cure temperature, and molding pressure will all potentially affect the drug release consistency and drug content uniformity of a manufacturing lot. In some cases, lamination or over molding of a thin, drug-free layer can be used to enable more uniform release of drug from the implant.